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Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/8198
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dc.contributor.authorArif Kamal, Md.-
dc.contributor.authorPal, Antara-
dc.date.accessioned2024-01-30T04:31:38Z-
dc.date.available2024-01-30T04:31:38Z-
dc.date.issued2023-09-20-
dc.identifier.citationColloids and Surfaces A: Physicochemical and Engineering Aspects,2023,Vol. 673, p131489en_US
dc.identifier.issn1873-4359 (Online)-
dc.identifier.urihttp://hdl.handle.net/2289/8198-
dc.descriptionRestricted Access.en_US
dc.description.abstractSterols have played an important role in membrane evolution. The effect of these molecules, particularly the naturally occurring ones, such as cholesterol, ergosterol, lanosterol, phytosterols and oxysterols on the properties of lipid model membranes have been extensively investigated. Unfortunately, other naturally occurring sterols such as desmosterol and lathosterol have received very little attention. Using small angle X-ray scattering (SAXS), we have carried out detailed investigations on the influence of desmosterol and lathosterol along with coprostanol on the phase behaviour of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) membranes. SAXS results indicate both that these sterols modulate the properties of the DPPC bilayer in a manner similar to cholesterol. However, we have found desmosterol to be more efficient than cholesterol in suppressing the main transition of DPPC, with the fluid phase stabilized at around 15 mol% (compared to around 20 mol% in cholesterol). Coprostanol on the other hand was found to be less efficient in stabilizing the fluid phase than the other two. The results obtained from our study in combination with those existing in the literature will help in establishing a complete picture of how different sterols influence the properties of lipid membranesen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urihttps://doi.org/10.1016/j.colsurfa.2023.131489en_US
dc.rights2023, The Author(s)en_US
dc.subjectDesmosterolen_US
dc.subjectLathosterolen_US
dc.subjectCoprostanolen_US
dc.subjectSAXSen_US
dc.subjectPhase behaviouren_US
dc.subjectDPPCen_US
dc.titleEffect of Desmosterol, Lathosterol and Coprostanol on the phase behaviour of phospholipid membranesen_US
dc.typeArticleen_US
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