Title:	Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.
Authors:	Banerjee, Deb Sankar Munjal, Akankshi Lecuit, Thomas Rao, Madan
Issue Date:	24-Oct-2017
Publisher:	Nature Publishing Group
Citation:	Nature Communications, 2017, Vol. 18, p1121
Abstract:	Tissue remodeling requires cell shape changes associated with pulsation and flow of the actomyosin cytoskeleton. Here we describe the hydrodynamics of actomyosin as a confined active elastomer with turnover of its components. Our treatment is adapted to describe the diversity of contractile dynamical regimes observed in vivo. When myosin-induced contractile stresses are low, the deformations of the active elastomer are affine and exhibit spontaneous oscillations, propagating waves, contractile collapse and spatiotemporal chaos. We study the nucleation, growth and coalescence of actomyosin-dense regions that, beyond a threshold, spontaneously move as a spatially localized traveling front. Large myosin-induced contractile stresses lead to nonaffine deformations due to enhanced actin and crosslinker turnover. This results in a transient actin network that is constantly remodeling and naturally accommodates intranetwork flows of the actomyosin-dense regions. We verify many predictions of our study in Drosophila embryonic epithelial cells undergoing neighbor exchange during germband extension.
Description:	Open Access
URI:	http://hdl.handle.net/2289/6836
ISSN:	2041-1723 (online)
Alternative Location:	https://arxiv.org/abs/1605.07318 http://dx.doi.org/10.1038/s41467-017-01130-1
Copyright:	2017 The authors
Appears in Collections:	Research Papers (TP)

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